Invited to speak at Symposium on Healthcare and Analytics in Research and Practice (SHARP 2014) as part of a panel on Analytics Powering Smart Cities and a session on Smart and Connected Cities. The use of big data and analytics approaches in the fields of science, technology and business is promising and set to grow over the next several years. The adoption of such approaches should lead toward the development of next-generation innovation that is widely adopted in organizations and localized communities but are also sharable over high-speed, gigabit cyber-networks such as the government’s Geni initiative. Analytics-driven developments in various spheres such as healthcare, smart grid, public health, consumer, etc. can strongly influence the technological evolution, guide policy making, while reshaping the future and catalyze the innovation culture at the global, regional and metropolitan levels. Various private and public open-data initiatives will be key drivers for this change. Such an approach requires a new thinking blended with state-of-art new business, technology and analytics skills and strong scientific research.